Name: Vaidehi Roy Chowdhury
Host Organisation: University of Cambridge, United Kingdom
Project Title: Rational design of a panel of antibodies targeting Nogo-A
Supervisor: Prof. Michele Vendruscolo
Objectives of the Project:
The goal of this IRP is the generation of a protein-specific and conformation-specific antibodies that recognise pre-selected epitopes
of Nogo-A, which is a challenging target associated with the Bio2Brain project. To achieve this goal we will exploit a method or rational antibody
design recently developed in our lab.
Secondments:
- LENS
- Task: To learn how to characterise by imaging the binding of antibodies to their targets in physiological environments
- Advisor: Dr. Martino Calamai
- Duration: 1 month
- VEC
- Task: To learn methods for industrial applications of therapeutic and pharmaceutical analysis
- Advisor: Prof. Dr. Thomas Beckert
- Duration: 1 month
- HBC
- Task: To learn to use advanced microscopy techniques to monitor the release of the designed antibodies
- Advisor: Prof. Dr. Katharina Schindowski
- Duration: 1 month
Short Biography:
Vaidehi received her degree of Master of Science in Biotechnology from the University of Calcutta, India, in 2021. During her Master’s course, she did a couple of internships whereby she learned some key techniques in plant tissue culture and transgenics, protein expression and purification in prokaryotes, computational analysis of protein structure networks and molecular docking.
She is currently working in the lab of Prof. Michele Vendruscolo in the University of Cambridge Centre for Misfolding Diseases. Her work principally focuses on antibody production and characterisation of antigen-antibody interactions. Besides academics, she has been learning various forms of Indian classical dance for the past one-and-half-decades.