Name: Natascia Ruggeri
Host Organisation: Biberach University of Applied Science, Germany
Project Title: Analysis of mAb transport and its dependency on Fc-interacting molecules in vitro, ex vivo and in vivo
Supervisor: Prof. Dr. Katharina Zimmermann
Objectives of the Project:
The overall goal of this project is the analysis of the transmucosal pathway through the nasal mucosa and the role of specific mucosal carriers.
The specific goals are:
- Molecular understanding of intranasal transmucosal delivery of antibodies to the CNS;
- Supporting the tailoring of antibodies or Fc fusion proteins according to the identified molecules involved in transport and immune interaction for an optimal and safe transport (antibody engineering);
- Cell line development and manufacturing of up to three engineered mAbs.
Short Biography:
- Bachelor’s degree in Biological Sciences from Università del Piemonte Orientale
- Master’s degree in Neurobiology from Università di Pavia
- Internship for bachelor`s thesis at the Umberto Parini hospital in Aosta in collaboration with the Consiglio Nazionale della Ricerca (CNR) to study acute exposure to hypoxia and oxidative stress
- 1-year internship for master’s thesis at Istituto Italiano di Tecnologia (IIT) on Next Generation Sequencing (NGS) sequencing and bioinformatic analyzes of gene variants associated with Parkinson’s disease