Project 4 – Analysis of mAb transport and its dependency on Fc-interacting molecules in vitro, ex vivo and in vivo

The overall goal of this subproject is the analysis of the transmucosal pathway through the nasal mucosa and the role of specific mucosal carriers.

The specific goals are:

  1. Molecular understanding of intranasal transmucosal delivery of antibodies to the CNS;
  2. Supporting the tailoring of antibodies or Fc fusion proteins according to the identified molecules involved in transport and immune interaction for an optimal and safe transport (antibody engineering);
  3. Cell line development and manufacturing of up to three engineered mAbs.

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