The overall goal of this subproject is the analysis of the transmucosal pathway through the nasal mucosa and the role of specific mucosal carriers.
The specific goals are:
- Molecular understanding of intranasal transmucosal delivery of antibodies to the CNS;
- Supporting the tailoring of antibodies or Fc fusion proteins according to the identified molecules involved in transport and immune interaction for an optimal and safe transport (antibody engineering);
- Cell line development and manufacturing of up to three engineered mAbs.