The overall goal of this subproject is the analysis of the transmucosal pathway through the nasal mucosa and the role of specific mucosal carriers.

The specific goals are:

  1. Molecular understanding of intranasal transmucosal delivery of antibodies to the CNS;
  2. Supporting the tailoring of antibodies or Fc fusion proteins according to the identified molecules involved in transport and immune interaction for an optimal and safe transport (antibody engineering);
  3. Cell line development and manufacturing of up to three engineered mAbs.