Project 1 - Particle-based formulations for the intransal transmucosal delivery of Biopharmaceuticals Project 2 – Bio-based hydrogels as drug delivery systems for the intranasal transmucosal delivery of Biopharmaceuticals Project 3 – (Bio)polymer-based particulate formulations for the intranasal transmucosal delivery of Biopharmaceuticals Project 4 – Analysis of mAb transport and its dependency on Fc-interacting molecules in vitro, ex vivo and in vivo Project 5 – Safe-by-Design Project 6 – Nose to Brain application of wildtype and engineered antibodies in the pathophysiological context in vivo Project 7 – Advanced imaging approaches for dissecting the mechanisms of release and trafficking of Biopharmaceuticals Project 8 – A computational approach to optimal design of DDS Project 9 – Development of new polymeric nanogels as drug delivery systems Project 10 – Development of new micro-polymers for intranasal drug delivery: study of interfacial behaviour with biological membranes Project 11 – Rational design of a panel of antibodies targeting Nogo-A Project 12 – Rational design of a panel of antibodies targeting LINGO-1 Project 13 – Hyaluronan based hydrogels for mucosal drug delivery